Spider-Man villain Doctor Octopus may also make his debut in the game that will be released for the PS4 in September. Chris Jai Alex, who plays Rhino in Spider-Man, spoke with Call of Duty YouTuber Drifter during an E3 video interview about this. The conversation was actually about being a multiplayer announcer in Black Ops 4. However, voice actors have several jobs at the same time and so it was also mentioned that he did Spider-Man and he called Doctor Octopus.
This villain is only not announced nor has it been announced that he is in the game, so the voice actor turned out to be too loose. Drift0r has removed the piece from his video, but fortunately there are always mirrors, as also below.
Doctor Octopus is a well-known villain of the franchise and the original boss of the Sinister Six. In the E3 trailer of Spider-Man there were already some hints (see here at 06:40 for example), but now it seems really sure that it is Doctor Octopus.